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Prevalence and influence of gastroesophageal reflux symptoms on sleep apnea and sleepiness

  • Dejan Radovanovic
    Affiliations
    Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Via G.B. Grassi 74, 20157, Milano, Italy
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  • Stefano Pini
    Affiliations
    Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Via G.B. Grassi 74, 20157, Milano, Italy

    Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Milano, Italy
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  • Maurizio Rizzi
    Affiliations
    Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Via G.B. Grassi 74, 20157, Milano, Italy
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  • Elisa Franceschi
    Affiliations
    Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Via G.B. Grassi 74, 20157, Milano, Italy

    Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Milano, Italy
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  • Pierachille Santus
    Correspondence
    Corresponding author.
    Affiliations
    Division of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Via G.B. Grassi 74, 20157, Milano, Italy

    Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Milano, Italy
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Published:December 03, 2020DOI:https://doi.org/10.1016/j.ejim.2020.11.022

      Highlights

      • Sleep apnea shares symptoms and risk factors with gastroesophageal reflux
      • A large cohort of patients with suspected sleep disturbances were screened
      • Non-obese sleep apnea patients are not at higher risk of having reflux symptoms
      • Nevertheless, daytime sleepiness correlated with gastroesophageal reflux
      • Gastroesophageal reflux should be ruled out in patients with bad sleep quality

      Keywords

      Abbreviations:

      OSA (obstructive sleep apnea), GERD (gastroesophageal reflux disease), PPI (proton pump inhibitors), PKY (pack year), ESS (Epworth Sleepiness Scale), AHI (apnea-hypopnea index), GerdQ (gastroesophageal reflux disease questionnaire), GerdQsd (gastroesophageal reflux disease questionnaire sum score for sleep disturbance), MMDL (mean maximum decibel level), BMI (body mass index), NONS (non-OSA non-snorers)
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      References

        • Young T
        • Palta M
        • Dempsey J
        • Skarrud J
        • Weber S
        • Badr S
        The occurrence of sleep disordered breathing among middle-aged adults.
        N Engl J Med. 1993; 328: 1230-1235https://doi.org/10.1056/NEJM199304293281704
        • Basoglu OK
        • Vardar R
        • Tasbakan MS
        • et al.
        Obstructive sleep apnea syndrome and gastroesophageal reflux disease: the importance of obesity and gender.
        Sleep breath. 2015; 19: 585-592https://doi.org/10.1007/s11325-014-1051-4
        • Mody R
        • Bolge SC
        • Kannan H
        • Fass R
        Effects of gastroesophageal reflux disease on sleep and outcomes.
        Clin Gastroenterol Hepatol. 2009; 7: 953-959https://doi.org/10.1016/j.cgh.2009.04.005
        • Orr WC
        • Robert JJ
        • Houck JR
        • et al.
        The effect of acid suppression on upper airway anatomy and obstruction in patients with sleep apnea and gastroesophageal reflux disease.
        J Clin Sleep Med. 2009; 15: 330-334https://doi.org/10.5664/jcsm.27543
        • Gren BT
        • Broughton WA
        • O'Connor JB
        Marked improvement in nocturnal gastroesophageal reflux in a large cohort of patients with obstructive sleep apnea treated with continuous positive airway pressure.
        Arch Intern Med. 2003; 163: 41-45https://doi.org/10.1001/archinte.163.1.41
        • Johns MW.
        A new method for measuring daytime sleepiness: The Epworth Sleepiness Scale.
        Sleep. 1991; 14: 540-545https://doi.org/10.1093/sleep/14.6.540
        • Jones R
        • Junghard O
        • Dent J
        • et al.
        Development of the GerdQ, a tool for the diagnosis and menagement of gastro-oesophageal reflux disease in primary care.
        Aliment Pharma Ther. 2009; 30: 1030-1036.https://doi.org/10.1111/j.1365-2036.2009.04142.x
      1. Berry RB, Brooks R, Gamaldo CE, et al. The AASM manual for the scoring of sleep and associated events. Rules, Terminology and Technical specification, version 2.2. American Academy of Sleep Medicine. Darien, IL, 2015.

        • Jung H
        • Choung RS
        • Talley NJ
        Gastroesophageal reflux disease and sleep disorders: evidence for a causal link and therapeutic implications.
        J. Neurogastroenterol Motl. 2010; 16: 22-29https://doi.org/10.5056/jnm.2010.16.1.22
        • Ing AJ
        • Ngu MC
        • Breslin AB
        Obstructive sleep apnea and gastroesophageal reflux.
        Am J Med. 2000; 108: S120-S125https://doi.org/10.1016/s0002-9343(99)00350-2