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From the CHA2DS2-VASc score to inflammation: a path leading to frailty? An update of the PURE-Rhythm Trial

  • Stefano Fumagalli
    Correspondence
    Corresponding Author: Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit; Department of Experimental and Clinical Medicine; University of Florence and AOU Careggi, Largo Brambilla, 3 – 50134 Florence, Italy.
    Affiliations
    Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, Department of Experimental and Clinical Medicine, University of Florence and AOU Careggi, Florence, Italy
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  • Claudia Di Serio
    Affiliations
    Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, Department of Experimental and Clinical Medicine, University of Florence and AOU Careggi, Florence, Italy
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  • Giulia Ricciardi
    Affiliations
    Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, Department of Experimental and Clinical Medicine, University of Florence and AOU Careggi, Florence, Italy
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  • Gregory Y.H. Lip
    Affiliations
    Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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  • Niccolò Marchionni
    Affiliations
    Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, Department of Experimental and Clinical Medicine, University of Florence and AOU Careggi, Florence, Italy
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  • for the PURE-Rhythm Trial Investigators
Published:December 16, 2020DOI:https://doi.org/10.1016/j.ejim.2020.12.001

      Highlights

      • A higher CHA2DS2-VASc score is correlated to higher cytokine levels
      • The CHA2DS2-VASc score is an expression of a complex clinical status
      • The CHA2DS2-VASc score is inversely associated with SPPB, an index of frailty
      • An association also exists between IL-6 levels and frailty
      • In AF, inflammation could mediate the link between CHA2DS2-VASc score and frailty

      Keywords

      Abbreviations:

      AF (atrial fibrillation), GDS (Geriatric Depression Scale), ECV (electrical cardioversion), IL-6 (interleukin-6), MMSE (Mini-Mental State Examination), OPG (osteoprotegerin), SPPB (Short Physical Performance Battery)
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