We are glad to share with Corredoira and colleagues the interest for our recently
published work regarding the relationship between Enteroccocus spp infective endocarditis (EIE) and colorectal neoplasm (CRN) [
[1]
]. In their letter to the Editor, entitled “Associating enterococcal endocarditis and
colorectal neoplasia: is colonoscopy mandatory?” [
[2]
], Correidora et al. highlight some of the key clinical features we also deem of utmost importance when
approaching a patient with EIE. Indeed, as underscored by our Spanish colleagues,
accumulating evidence from several retrospective studies supports the usefulness of
colonoscopy not only in Streptococcus gallolyticus endocarditis but also in EIE, irrespective of whether the focus of infection is obvious
or unknown [
[1]
,
[2]
]. However, whether E. faecalis or S. gallolyticus infective endocarditis/bacteremia are an epiphenomenon of an already established
CRN or play an active role in colorectal mucosal cell carcinogenesis remains unclear.Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Enterococcal infective endocarditis is a marker of current occult or future incident colorectal neoplasia.Eur J Intern Med. 2020; S0953-6205: 30383-30386
- Associating enterococcal endocarditis and colorectal neoplasia: is colonoscopy mandatory?.Eur J Intern Med. 2020; S0953-6205: 30423-30424
- Colorectal cancer genetics, incidence and risk factors: in search for targeted therapies.Cancer Manag Res. 2020; 12: 9869-9882
- A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects.Nat Rev Microbiol. 2012; 10: 575-582
- Clinical implications of the associations between intestinal microbiome and colorectal cancer progression.Cancer Manag Res. 2020; 12: 4117-4128
- Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.Science. 2018; 359: 592-597
- Bacterially-associated transcriptional remodelling in a distinct genomic subtype of colorectal cancer provides a plausible molecular basis for disease development.PLoS ONE. 2016; 11e0166282
- Real-time polymerase chain reaction quantification of specific butyrate-producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer.J Gastroenterol Hepatol. 2008; 23: 1298-1303
- Assessment of oncogenic role of intestinal microbiota in colorectal cancer patients.J Gastrointest Cancer. 2020; (Epub ahead of print)
- Extracellular superoxide production by Enterococcus faecalis promotes chromosomal instability in mammalian cells.Gastroenterology. 2007; 132: 551-561
- Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect.Cancer Res. 2008; 68: 9909-9917
- Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation.Gastroenterology. 2011; 141: 959-971
- The controversial role of Enterococcus faecalis in colorectal cancer.Therap Adv Gastroenterol. 2018; 111756284818783606
- Quantitative profiling of colorectal cancer-associated bacteria reveals associations between fusobacterium spp., enterotoxigenic bacteroides fragilis (ETBF) and clinicopathological features of colorectal cancer.PLoS One. 2015; 10e0119462
- Differential responses of colorectal cancer cell lines to enterococcus faecalis' strains isolated from healthy donors and colorectal cancer patients.J Clin Med. 2019; 8: 388
Article info
Publication history
Published online: December 31, 2020
Accepted:
December 24,
2020
Received:
December 5,
2020
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.