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How specific are elevated IgG4 levels for IgG4-related disease?

  • Author Footnotes
    1 Joint first authors.
    M. Schils
    Footnotes
    1 Joint first authors.
    Affiliations
    Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Gastroenterology, University Hospitals Brussels, Brussels, Belgium
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  • Author Footnotes
    1 Joint first authors.
    A. Betrains
    Correspondence
    Corresponding author at: Department of General Internal Medicine - University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
    Footnotes
    1 Joint first authors.
    Affiliations
    Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium
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  • S. Vanderschueren
    Affiliations
    Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium
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  • X. Bossuyt
    Affiliations
    Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium
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  • D. Blockmans
    Affiliations
    Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium
    Search for articles by this author
  • Author Footnotes
    1 Joint first authors.
Published:February 01, 2021DOI:https://doi.org/10.1016/j.ejim.2021.01.013

      Highlights

      • Elevated IgG4 levels and IgG4/IgG ratios are not specific for IgG4-RD.
      • IgG4-RD causes most elevated IgG4 levels high above the upper limit of normal.
      • Even at very high serum IgG4 levels, 25% of patients did not have IgG4-RD.

      Keywords

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