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Letter to the Editor| Volume 87, P115-118, May 2021

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How specific are elevated IgG4 levels for IgG4-related disease?

  • Author Footnotes
    1 Joint first authors.
    M. Schils
    Footnotes
    1 Joint first authors.
    Affiliations
    Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Gastroenterology, University Hospitals Brussels, Brussels, Belgium
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  • Author Footnotes
    1 Joint first authors.
    A. Betrains
    Correspondence
    Corresponding author at: Department of General Internal Medicine - University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
    Footnotes
    1 Joint first authors.
    Affiliations
    Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium
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  • S. Vanderschueren
    Affiliations
    Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium
    Search for articles by this author
  • X. Bossuyt
    Affiliations
    Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium
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  • D. Blockmans
    Affiliations
    Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium

    Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium
    Search for articles by this author
  • Author Footnotes
    1 Joint first authors.
Published:February 01, 2021DOI:https://doi.org/10.1016/j.ejim.2021.01.013
How specific are elevated IgG4 levels for IgG4-related disease?
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      Highlights

      • •
        Elevated IgG4 levels and IgG4/IgG ratios are not specific for IgG4-RD.
      • •
        IgG4-RD causes most elevated IgG4 levels high above the upper limit of normal.
      • •
        Even at very high serum IgG4 levels, 25% of patients did not have IgG4-RD.

      Keywords

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      References

        • Stone JH
        • Zen Y
        • Deshpande V.
        IgG4-related disease.
        N Engl J Med. 2012; 366: 539-551
        View in Article
        • Nirula A
        • Glaser SM
        • Kalled SL
        • Taylor FR
        • Taylora FR.
        What is IgG4? A review of the biology of a unique immunoglobulin subtype.
        Curr Opin Rheumatol. 2011; 23: 119-124
        View in Article
        • Carruthers MN
        • Khosroshahi A
        • Augustin T
        • Deshpande V
        • Stone JH.
        The diagnostic utility of serum IgG4 concentrations in IgG4-related disease.
        Ann Rheum Dis. 2015; 74: 14-18
        View in Article
        • Ryu JH
        • Horie R
        • Sekiguchi H
        • Peikert T
        • Yi ES.
        Spectrum of disorders associated with elevated serum IgG4 levels encountered in clinical practice.
        Int J Rheumatol. 2012; https://doi.org/10.1155/2012/232960
        View in Article
        • Ebbo M
        • Grados A
        • Bernit E
        • Vély F
        • Boucraut J
        • Harlé J-R
        • et al.
        Pathologies associated with serum IgG4 elevation.
        Int J Rheumatol. 2012; https://doi.org/10.1155/2012/602809
        View in Article
        • Culver EL
        • Sadler R
        • Simpson D
        • Cargill T
        • Makuch M
        • Bateman AC
        • et al.
        Elevated serum IgG4 levels in diagnosis, treatment response, organ involvement, and relapse in a prospective IgG4-related disease UK cohort.
        Am J Gastroenterol. 2016; 111: 733-743
        View in Article
        • Khosroshahi A
        • Wallace ZS
        • Crowe JL
        • Akamizu T
        • Azumi A
        • Carruthers M
        • et al.
        International consensus guidance statement on the management and treatment of IgG4-related disease.
        Arthritis Rheumatol. 2015; 67: 1688-1699
        View in Article
        • Yamamoto M
        • Tabeya T
        • Naishiro Y
        • Yajima H
        • Ishigami K
        • Shimizu Y
        • et al.
        Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases.
        Mod Rheumatol. 2012; 22: 419-425
        View in Article
        • Khosroshahi A
        • Cheryk LA
        • Carruthers MN
        • Edwards JA
        • Bloch DB
        • Stone JH.
        Brief Report: spuriously low serum IgG4 concentrations caused by the prozone phenomenon in patients with IgG4-related disease.
        Arthritis Rheumatol. 2014; 66: 213-217
        View in Article

      Article info

      Publication history

      Published online: February 01, 2021
      Accepted: January 14, 2021
      Received in revised form: December 31, 2020
      Received: November 21, 2020

      Identification

      DOI: https://doi.org/10.1016/j.ejim.2021.01.013

      Copyright

      © 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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