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Multidisciplinary prevention and management strategies for colorectal cancer and cardiovascular disease

Published:February 17, 2021DOI:https://doi.org/10.1016/j.ejim.2021.02.003

      Highlights

      • CRC and CVD share many modifiable risk factors and synergistic prevention strategies could reduce morbidity and mortality for both diseases.
      • CVD screening that identifies high-risk patients should prompt consideration for CRC risk assessment and vice versa.
      • Practical guidelines for cardio-oncologic shared disease prevention and management are needed.

      Abstract

      Colorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide. Their numerous shared and modifiable risk factors underscore the importance of effective prevention strategies for these largely preventable diseases. Conventionally regarded as separate disease entities, clear pathophysiological links and overlapping risk factors represent an opportunity for synergistic collaborative efforts of oncologists and cardiologists. In addition, current CRC treatment approaches can exert cardiotoxicity and thus increase CVD risk. Given the complex interplay of both diseases and increasing numbers of CRC survivors who are at increased risk for CVD, multidisciplinary cardio-oncological approaches are warranted for optimal patient care from primary prevention to acute disease treatment and long-term surveillance.

      Keywords

      Abbreviations:

      ACC/AHA (American College of Cardiology/American Heart Association), ACG (American College of Gastroenterology), AGA (American Gastroenterological Association), ASCO (American Society of Clinical Oncology), ASCVD (Atherosclerotic cardiovascular disease), ASGE (American Society for Gastrointestinal Endoscopy), BMI (Body mass index), CVD (Cardiovascular disease), CHF (Congestive heart failure), CRC (Colorectal cancer), FIT (Fecal immunochemical test), gFOBT (guaiac-based fecal occult blood test), LVEF (Left ventricular ejection fraction), NSAID (Non-steroidal anti-inflammatory drugs), RCT (Randomized controlled trial), US (United States), USPSTF (U.S. Preventive Services Task Force)
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