Highlights
- •Rheumatoid arthritis is a multi-factorial disease with a certain genetic risk.
- •Most genetic risks are determined by the HLA-DRB1 gene, Non-HLA genes may be related to RA susceptibility and regulate disease risk.
- •TGF gene polymorphism may be associated with RA susceptibility.
- •Transforming growth factor genotype may determine the severity of bone damage and predict the progression of rheumatoid arthritis.
Abstract
Rheumatoid arthritis (RA) is a complex autoimmune disease that affects about 1% of
the world's population. The conclusions about the relationship between TGF gene polymorphism
and the risk of RA are still inconsistent. Therefore, we performed a meta-analysis
to re-evaluate the relationship between TGF-β1 T869C gene polymorphism and the risk
of rheumatoid arthritis.
Method: We performed a systematic electronic search in PubMed, Embase, Elsevier, Web
of Science, Cochrane Library, Medline and China National Knowledge Infrastructure
database (up to August 2020). In the subgroup analysis, we divide the research into
three groups: Asian, European and Mediterranean, The combined OR and 95%CI of the
five models (allele model, homozygous model, heterozygous model, dominant model, recessive
model) were calculated, respectively.
Results: 15 case-control studies (14 articles) were involved in this meta-analysis,
including 2103 cases and 2143 healthy controls. In the overall analysis, it showed
that there may be an significant association between TGF-β1+869T/C polymorphism and
RA sensitivity (allele model, T vs. C: OR=1.444, 95% CI=1.171-1.782, P=0.001; homozygous
model, TT vs. CC: OR=1.910, 95% CI=1.322-2.761, P=0.001; heterozygous model, CT vs.
CC: OR=1.558, 95% CI=1.179-2.059,P=0.002; dominant model, TT+CT vs. CC: OR= 1.742,
95% CI=1.303-2.329, P=0.001; recessive model, TT vs. CT+CC: OR=1.400, 95% CI= 1.058-1.852,
P=0.018).However, the results of ethnic subgroup analysis indicated that rs1982073
was not associated with RA risk in Europeans(allele model, T vs. C: OR=0.993, 95%
CI=0.849-1.162, P=0.931, I2 <0.1%, P>0.1).
Conclusion: In summary, our meta-analysis showed that the rs1982073 T allele does
not increase RA susceptibility in Europeans.
Keywords
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Article info
Publication history
Published online: February 22, 2021
Accepted:
February 8,
2021
Received in revised form:
January 15,
2021
Received:
November 21,
2020
Identification
Copyright
© 2021 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.
