Colorectal cancer (CRC) and cardiovascular diseases (CVD) are amongst the two leading
causes of death in western countries and have dramatic impact on the financial sustainability
of the health systems [
[1]
,
[2]
]. Both diseases share several modifiable risk factors, genetic features and biological
pathways. In the last decade emerging data suggest that this link is particularly
relevant in patients with CRC [
[3]
]: i) obesity, an inflammatory syndrome, increases the risk and predict prognosis of
CRC patients ii) patients diagnosed with CVD have a higher prevalence of colorectal
neoplasms compared to patients without CVD, iii) in asymptomatic patients, colorectal
adenoma has been associated with coronary artery calcification and stenosis severity,
iv) diabetes mellitus, alcohol, tobacco and obesity increase the risk of long term
CVD in patients previously exposed to systemic cancer therapy, v) large clinical studies
investigating non-steroidal anti-inflammatory drugs have been shown to reduce incidence
and mortality in cancer.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Published online: March 26, 2021
Accepted:
March 14,
2021
Received:
March 9,
2021
Identification
Copyright
© 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
