Sepsis is defined as a dysregulated host response to several types of infections [
[1]
], still representing a challenging issue in Medicine. Atrial Fibrillation (AF) frequently
occurs in patients with sepsis and septic shock [
[2]
], representing one difficult challenge for treating physicians: increased heart rate
and loss of atrial kick worsen myocardial function and cardiac output [
- Meierhenrich R
- Steinhilber E
- Eggermann C
- et al.
Incidence and prognostic impact of new-onset atrial fibrillation in patients with
septic shock: a prospective observational study.
Crit Care. 2010; 14 ([Internet]Available from: https://www.embase.com/search/results?subaction=viewrecord&id=L50951461&from=export
NS -)
[3]
]. Unsurprisingly, AF has been consistently associated with worse outcomes in sepsis
patients [
- Klein Klouwenberg PMC
- Frencken JF
- Kuipers S
- et al.
Incidence, predictors, and outcomes of new-onset atrial fibrillation in critically
ill patients with sepsis a cohort study.
Am J Respir Crit Care Med. 2017; 195 ([Internet][cited 2020 Nov 10]Available from: https://pubmed.ncbi.nlm.nih.gov/27467907/): 205-211
[3]
].- Klein Klouwenberg PMC
- Frencken JF
- Kuipers S
- et al.
Incidence, predictors, and outcomes of new-onset atrial fibrillation in critically
ill patients with sepsis a cohort study.
Am J Respir Crit Care Med. 2017; 195 ([Internet][cited 2020 Nov 10]Available from: https://pubmed.ncbi.nlm.nih.gov/27467907/): 205-211
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References
- Surviving sepsis campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 [Internet].Crit Care Med. 2017; 45 ([cited 2020 Nov 10]Available from: https://pubmed.ncbi.nlm.nih.gov/28098591/): 486-552
- Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock: a prospective observational study.Crit Care. 2010; 14 ([Internet]Available from: https://www.embase.com/search/results?subaction=viewrecord&id=L50951461&from=export NS -)
- Incidence, predictors, and outcomes of new-onset atrial fibrillation in critically ill patients with sepsis a cohort study.Am J Respir Crit Care Med. 2017; 195 ([Internet][cited 2020 Nov 10]Available from: https://pubmed.ncbi.nlm.nih.gov/27467907/): 205-211
- Impact of atrial fibrillation in critically ill patients admitted to a stepdown unit.Eur J Clin Invest. 2020; 50: e13317
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Viswanathan M, Ansari M, Berkman N, et al. Methods guide for comparative effectiveness reviews assessing the risk of bias of individual studies in systematic reviews of health care interventions. 2012;12-EHC047-EF.
- Practice patterns and outcomes of treatments for atrial fibrillation during sepsis a propensity-matched cohort study.Chest. 2016; 149 ([Internet][cited 2020 Nov 17]Available from: https://pubmed.ncbi.nlm.nih.gov/26270396/): 74-83
- Propafenone for supraventricular arrhythmias in septic shock—comparison to amiodarone and metoprolol.J Crit Care. 2017; 41 ([Internet][cited 2020 Nov 17]Available from: https://pubmed.ncbi.nlm.nih.gov/28463737/): 16-23
- Comparative effectiveness of heart rate control medications for the treatment of sepsis-associated atrial fibrillation.Chest. 2020;
Article info
Publication history
Published online: April 24, 2021
Accepted:
March 29,
2021
Received:
March 21,
2021
Identification
Copyright
© 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
