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Impact of rate control in hospitalized patients with atrial fibrillation and sepsis

  • Author Footnotes
    1 Both authors equally contributed to each aspect of the manuscript.
    Giulio Francesco Romiti
    Footnotes
    1 Both authors equally contributed to each aspect of the manuscript.
    Affiliations
    Department of Translational and Precision Medicine, Sapienza – University of Rome, Rome, Italy
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  • Author Footnotes
    1 Both authors equally contributed to each aspect of the manuscript.
    Marco Proietti
    Correspondence
    Corresponding author at: IRCCS Istituti Clinici Scientifici Maugeri, Via Camaldoli 64, 20138, Milan, Italy.
    Footnotes
    1 Both authors equally contributed to each aspect of the manuscript.
    Affiliations
    Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

    Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy

    Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.
    Search for articles by this author
  • Author Footnotes
    1 Both authors equally contributed to each aspect of the manuscript.
Published:April 24, 2021DOI:https://doi.org/10.1016/j.ejim.2021.03.033
      Sepsis is defined as a dysregulated host response to several types of infections [
      • Rhodes A
      • Evans LE
      • Alhazzani W
      • et al.
      Surviving sepsis campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 [Internet].
      ], still representing a challenging issue in Medicine. Atrial Fibrillation (AF) frequently occurs in patients with sepsis and septic shock [
      • Meierhenrich R
      • Steinhilber E
      • Eggermann C
      • et al.
      Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock: a prospective observational study.
      ], representing one difficult challenge for treating physicians: increased heart rate and loss of atrial kick worsen myocardial function and cardiac output [
      • Klein Klouwenberg PMC
      • Frencken JF
      • Kuipers S
      • et al.
      Incidence, predictors, and outcomes of new-onset atrial fibrillation in critically ill patients with sepsis a cohort study.
      ]. Unsurprisingly, AF has been consistently associated with worse outcomes in sepsis patients [
      • Klein Klouwenberg PMC
      • Frencken JF
      • Kuipers S
      • et al.
      Incidence, predictors, and outcomes of new-onset atrial fibrillation in critically ill patients with sepsis a cohort study.
      ].
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      References

        • Rhodes A
        • Evans LE
        • Alhazzani W
        • et al.
        Surviving sepsis campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 [Internet].
        Crit Care Med. 2017; 45 ([cited 2020 Nov 10]Available from: https://pubmed.ncbi.nlm.nih.gov/28098591/): 486-552
        • Meierhenrich R
        • Steinhilber E
        • Eggermann C
        • et al.
        Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock: a prospective observational study.
        Crit Care. 2010; 14 ([Internet]Available from: https://www.embase.com/search/results?subaction=viewrecord&id=L50951461&from=export NS -)
        • Klein Klouwenberg PMC
        • Frencken JF
        • Kuipers S
        • et al.
        Incidence, predictors, and outcomes of new-onset atrial fibrillation in critically ill patients with sepsis a cohort study.
        Am J Respir Crit Care Med. 2017; 195 ([Internet][cited 2020 Nov 10]Available from: https://pubmed.ncbi.nlm.nih.gov/27467907/): 205-211
        • Falsetti L
        • Proietti M
        • Zaccone V
        • et al.
        Impact of atrial fibrillation in critically ill patients admitted to a stepdown unit.
        Eur J Clin Invest. 2020; 50: e13317
        • Stroup DF
        • Berlin JA
        • Morton SC
        • et al.
        Meta-analysis of observational studies in epidemiology: a proposal for reporting.
        J Am Med Assoc. 2000; 283 ([Internet][cited 2021 Feb 7]Available from:): 2008-2012
      1. Viswanathan M, Ansari M, Berkman N, et al. Methods guide for comparative effectiveness reviews assessing the risk of bias of individual studies in systematic reviews of health care interventions. 2012;12-EHC047-EF.

        • Walkey AJ
        • Evans SR
        • Winter MR
        • Benjamin EJ
        Practice patterns and outcomes of treatments for atrial fibrillation during sepsis a propensity-matched cohort study.
        Chest. 2016; 149 ([Internet][cited 2020 Nov 17]Available from: https://pubmed.ncbi.nlm.nih.gov/26270396/): 74-83
        • Balik M
        • Kolnikova I
        • Maly M
        • Waldauf P
        • Tavazzi G
        • Kristof J
        Propafenone for supraventricular arrhythmias in septic shock—comparison to amiodarone and metoprolol.
        J Crit Care. 2017; 41 ([Internet][cited 2020 Nov 17]Available from: https://pubmed.ncbi.nlm.nih.gov/28463737/): 16-23
        • Bosch NA
        • Rucci JM
        • Massaro JM
        • et al.
        Comparative effectiveness of heart rate control medications for the treatment of sepsis-associated atrial fibrillation.
        Chest. 2020;