Calsolaro V and colleagues indicated significant benefits of oral anticoagulants (OAC)
in oldest-old patients with atrial fibrillation (AF) in the previously published article,
entitled “Long-term effectiveness and safety of anticoagulation therapy in oldest
old, frail people with atrial fibrillation [
[1]
].” Since AF is the most common sustained cardiac arrhythmia related with worse clinical
outcomes [
[2]
] and is increasing in prevalence and incidence worldwide in this ageing society [
[3]
], clarifying the best care for these patients is crucial. Furthermore, older patients
tend to have higher risks regarding both embolism and bleeding, their investigation
in this population is quite remarkable and insightful.To read this article in full you will need to make a payment
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References
- Long-term effectiveness and safety of anticoagulation therapy in oldest old, frail people with atrial fibrillation.Eur J Intern Med. 2021; 86: 91-97https://doi.org/10.1016/j.ejim.2021.01.020
- Impact of atrial fibrillation on the risk of death: the Framingham Heart Study.Circulation. 1998; 98: 946-952https://doi.org/10.1161/01.cir.98.10.946
- Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study.Circulation. 2014; 129: 837-847https://doi.org/10.1161/CIRCULATIONAHA.113.005119
- Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials.Lancet. 2014; 383: 955-962https://doi.org/10.1016/S0140-6736(13)62343-0
- Dabigatran versus warfarin in patients with mechanical heart valves.N Engl J Med. 2013; 369: 1206-1214https://doi.org/10.1056/NEJMoa1300615
- Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample.J Am Coll Cardiol. 1993; 21: 1220-1225https://doi.org/10.1016/0735-1097(93)90249-z
- Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study).Am J Cardiol. 1999; 83: 897-902https://doi.org/10.1016/s0002-9149(98)01064-9
Article info
Publication history
Published online: May 21, 2021
Accepted:
May 1,
2021
Received:
April 18,
2021
Identification
Copyright
© 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
