Advertisement

Type of anticoagulation therapy in oldest old, frail people with atrial fibrillation

  • Atsuyuki Watanabe
    Correspondence
    Corresponding author at: Department of Cardiovascular Surgery, University of Tsukuba Hospital 2-1-1, Amakubo, Tsukuba, Ibaraki 305-8576, Japan.
    Affiliations
    Department of Cardiovascular Surgery, University of Tsukuba Hospital
    Search for articles by this author
      Calsolaro V and colleagues indicated significant benefits of oral anticoagulants (OAC) in oldest-old patients with atrial fibrillation (AF) in the previously published article, entitled “Long-term effectiveness and safety of anticoagulation therapy in oldest old, frail people with atrial fibrillation [
      • Calsolaro V
      • Okoye C
      • Antognoli R
      • Dell'Agnello U
      • Calabrese AM
      • Monzani F.
      Long-term effectiveness and safety of anticoagulation therapy in oldest old, frail people with atrial fibrillation.
      ].” Since AF is the most common sustained cardiac arrhythmia related with worse clinical outcomes [
      • Benjamin EJ
      • Wolf PA
      • D'Agostino RB
      • Silbershatz H
      • Kannel WB
      • Levy D
      Impact of atrial fibrillation on the risk of death: the Framingham Heart Study.
      ] and is increasing in prevalence and incidence worldwide in this ageing society [
      • Chugh SS
      • Havmoeller R
      • Narayanan K
      • Singh D
      • Rienstra M
      • Benjamin EJ
      • et al.
      Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study.
      ], clarifying the best care for these patients is crucial. Furthermore, older patients tend to have higher risks regarding both embolism and bleeding, their investigation in this population is quite remarkable and insightful.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Calsolaro V
        • Okoye C
        • Antognoli R
        • Dell'Agnello U
        • Calabrese AM
        • Monzani F.
        Long-term effectiveness and safety of anticoagulation therapy in oldest old, frail people with atrial fibrillation.
        Eur J Intern Med. 2021; 86: 91-97https://doi.org/10.1016/j.ejim.2021.01.020
        • Benjamin EJ
        • Wolf PA
        • D'Agostino RB
        • Silbershatz H
        • Kannel WB
        • Levy D
        Impact of atrial fibrillation on the risk of death: the Framingham Heart Study.
        Circulation. 1998; 98: 946-952https://doi.org/10.1161/01.cir.98.10.946
        • Chugh SS
        • Havmoeller R
        • Narayanan K
        • Singh D
        • Rienstra M
        • Benjamin EJ
        • et al.
        Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study.
        Circulation. 2014; 129: 837-847https://doi.org/10.1161/CIRCULATIONAHA.113.005119
        • Ruff CT
        • Giugliano RP
        • Braunwald E
        • Hoffman EB
        • Deenadayalu N
        • Ezekowitz MD
        • et al.
        Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials.
        Lancet. 2014; 383: 955-962https://doi.org/10.1016/S0140-6736(13)62343-0
        • Eikelboom JW
        • Connolly SJ
        • Brueckmann M
        • Granger CB
        • Kappetein AP
        • Mack MJ
        • et al.
        Dabigatran versus warfarin in patients with mechanical heart valves.
        N Engl J Med. 2013; 369: 1206-1214https://doi.org/10.1056/NEJMoa1300615
        • Lindroos M
        • Kupari M
        • Heikkilä J
        • Tilvis R.
        Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample.
        J Am Coll Cardiol. 1993; 21: 1220-1225https://doi.org/10.1016/0735-1097(93)90249-z
        • Singh JP
        • Evans JC
        • Levy D
        • Larson MG
        • Freed LA
        • Fuller DL
        • et al.
        Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study).
        Am J Cardiol. 1999; 83: 897-902https://doi.org/10.1016/s0002-9149(98)01064-9