18F-FDG PET-CT versus contrast enhanced CT for the diagnosis of fever of unknown origin

Published:September 27, 2021DOI:https://doi.org/10.1016/j.ejim.2021.09.006
      Fever of unknown origin (FUO), also known as pyrexia of unknown origin, is commonly defined according to the Petersdorf criteria as fever ≥38.3° (101 Fahrenheit) lasting ≥3 weeks that remains undiagnosed after 1 week of investigations [
      • PETERSDORF RG
      • BEESON PB
      Fever of unexplained origin: report on 100 cases.
      ]. The last criterion has recently undergone modification, and is now generally interpreted as no diagnosis after appropriate inpatient or outpatient evaluation [
      • Meller J
      • Sahlmann CO
      Scheel AK 18F-FDG PET and PET/CT in fever of unknown origin.
      ]. Causes of FUO include more than 200 diseases [
      • Kan Y
      • Wang W
      • Liu J
      • Yang J
      • Wang Z
      Contribution of 18F-FDG PET/CT in a case-mix of fever of unknown origin and inflammation of unknown origin: a meta-analysis.
      ], but the three major pathological categories are represented by infections, malignancies, and non-infectious inflammatory diseases.
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