Does early systemic sclerosis really exist?

Published:December 27, 2021DOI:


      • A prompt detection of the different manifestations of systemic sclerosis affects prognosis but it is challenging in early stages when most of the typical signs are absent.
      • Patients with Raynaud phenomenon, abnormal findings in systemic sclerosis nailfold capillary pattern and the presence of specific autoantibody at baseline had very high probability of developing definite systemic sclerosis in the follow-up.
      • Internal organ involvement could be present since the early phase of the disease.



      SSc (Systemic Sclerosis)
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