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One-year mepolizumab for Allergic bronchopulmonary aspergillosis: Focus on steroid sparing effect and markers of response

Published:January 06, 2022DOI:https://doi.org/10.1016/j.ejim.2021.12.026
      Allergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity reaction to Aspergillus fumigatus, mainly characterized by severe asthma symptoms, hyper eosinophilia in blood, lung and airways, elevated serum IgE levels, bronchiectasis, bronchial mucoid impaction and lung fibrosis [
      • Agarwal R.
      • Sehgal I.
      • Dhooria S.
      • Muthu V.
      • Prasad K.
      • Bal A.
      • et al.
      Allergic bronchopulmonary aspergillosis.
      ]. As recently remarked, oral corticosteroids (OCS) and antifungal therapy currently represent the gold standard treatment [
      • Agarwal R.
      • Muthu V.
      • Sehgal I.S.
      • Dhooria S.
      • Prasad K.T.
      • Garg M.
      • et al.
      A randomised trial of prednisolone versus prednisolone and itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma.
      ]; however, despite their proven efficacy, they may cause severe side effects, especially in the case of prolonged therapy.

      Key words

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