If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password
If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password
A 67-year-old man had a medical history of type 2 diabetes mellitus, dyslipidemia, hypertension, and alcohol-related liver disease. His vital signs were normal, and he had no symptoms. On physical examination, he had bilateral diagonal earlobe creases running backward from the tragus at a 45⁰ angle across the lobule to the rear edge of the auricle (Fig. 1). What is the clinical significance of this sign?
Fig. 1Bilateral diagonal earlobe creases running backward from the tragus at a 45⁰ angle across the lobule to the rear edge of the auricle (arrows).
]. Earlobe ceases occur more frequently with increasing age; however, a large prospective population study demonstrated that the presence of an earlobe crease is associated with increased risks of ischemic heart disease and myocardial infarction independent of age and other well-known cardiovascular risk factors [
]. In the present case, further questioning of the patient revealed that he underwent percutaneous coronary intervention for acute myocardial infarction at 40 years old. Frank's sign is an easily detectable predictor of CAD. Routine inspection of the earlobes may inform physicians on the patients’ backgrounds and clinical conditions.