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Is malignancy cancer an adverse factor of in-hospital clinical outcome in post-cardiac arrest?

Published:February 16, 2022DOI:https://doi.org/10.1016/j.ejim.2022.02.015
      With the continuous development of cancer treatment, patients with cancer have dramatically improved, with several cancer populations experiencing a median survival well beyond 5 years.
      • Siegel RL
      • Miller KD
      • Jemal A.
      Cancer statistics, 2018.
      However, malignancy cancer has an innegligible impact on the cardiovascular system, not only the cancer itself, but also the adverse effects of treatments (drugs or radiation). Recently, increasing data have shown that cancer survivors have increased rates of major cardiovascular events, including cardiac arrest, with poorer outcomes.
      • Bruckel JT
      • Wong SL
      • Chan PS
      • Bradley SM
      Nallamothu BK. Patterns of resuscitation care and survival after in-hospital cardiac arrest in patients with advanced cancer.
      However, it remains controversial whether the malignant cancer is a risk factor of in-hospital death in cardiac arrest patient. Champigneulle al and Winther et al reported that cancer is not associated with higher short or long-term mortality after successful resuscitation from out of hospital cardiac arrest when adjusting for prognostic factors.
      • Champigneulle B
      • Merceron S
      • Lemiale V
      • et al.
      What is the outcome of cancer patients admitted to the ICU after cardiac arrest? Results from a multicenter study.
      ,
      • Winther-Jensen M
      • Kjaergaard J
      • Hassager C
      • Køber L
      • Lippert F
      • Søholm H.
      Cancer is not associated with higher short or long-term mortality after successful resuscitation from out-of-hospital cardiac arrest when adjusting for prognostic factors.
      These findings still need further confirmation. Therefore, the aim of present study was to investigate whether a history of malignant cancer is associated with poor clinical outcome in post-cardiac arrest patients.

      Keyword

      Abbreviations:

      cardiac arrest (CA), acute physiology score II (APSII), sequential organ failure assessment (SOFA), International Classification of Diseases (ICD), Medical Information Mart for Intensive Care-IV (The MIMIC-IV), Kaplan–Meier (K-M), Propensity score matching (PSM)
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      References

        • Siegel RL
        • Miller KD
        • Jemal A.
        Cancer statistics, 2018.
        CA Cancer J Clin. 2018; 68: 7-30
        • Bruckel JT
        • Wong SL
        • Chan PS
        • Bradley SM
        Nallamothu BK. Patterns of resuscitation care and survival after in-hospital cardiac arrest in patients with advanced cancer.
        J Oncol Pract. 2017; 13: e821-e830
        • Champigneulle B
        • Merceron S
        • Lemiale V
        • et al.
        What is the outcome of cancer patients admitted to the ICU after cardiac arrest? Results from a multicenter study.
        Resuscitation. 2015; 92: 38-44
        • Winther-Jensen M
        • Kjaergaard J
        • Hassager C
        • Køber L
        • Lippert F
        • Søholm H.
        Cancer is not associated with higher short or long-term mortality after successful resuscitation from out-of-hospital cardiac arrest when adjusting for prognostic factors.
        Eur Heart J Acute Cardiovasc Care. 2020; 9 (4_suppl): S184-S192
        • Nordby H
        • Nøhr Ø
        The ethics of resuscitation: how do paramedics experience ethical dilemmas when faced with cancer patients with cardiac arrest?.
        Prehosp Disaster Med. 2012; 27: 64-70
        • Sandroni C
        • Nolan J
        • Cavallaro F
        • Antonelli M
        In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival.
        Intensive Care Med. 2007; 33: 237-245
        • Issa MS
        • Grossestreuer AV
        • Patel H
        • et al.
        Lactate and hypotension as predictors of mortality after in-hospital cardiac arrest.
        Resuscitation. 2021; 158: 208-214
        • Johnson A.
        • Bulgarelli L.
        • Pollard T.
        • Horng S.
        • Celi L.A.
        • Mark R.
        MIMIC-IV (version 1.0).
        PhysioNet. 2021; https://doi.org/10.13026/s6n6-xd98