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Diabetes influences the performance of creatinine-based equations for estimating glomerular filtration rate in the elderly population

Published:February 20, 2022DOI:https://doi.org/10.1016/j.ejim.2022.02.018
      The number of people older than 65 years with diabetes was 135.6 million in 2019, and will reach 276.2 million by 2045 [
      • Sinclair A.
      • Saeedi P.
      • Kaundal A.
      • Karuranga S.
      • Malanda B.
      • Williams R.
      Diabetes and global ageing among 65-99-year-old adults: Findings from the International Diabetes Federation Diabetes Atlas, 9(th) edition.
      ]. Additionally, the estimated prevalence of diabetes in adults today has reached 537 million (10.5% of the global population in 2021) [
      International Diabetes Federation
      IDF Diabetes Atlas—10th Edition.
      ]. Population aging and increasing prevalence of diabetes are two important factors associated with an increasing incidence of chronic kidney disease (CKD). An accurate estimation of glomerular filtration rate (GFR) can help with the identification and management of CKD. Because measured GFR (mGFR) is inconvenient and costly for daily clinical work, the use of GFR-estimating equations has become more common. However, there are very limited studies evaluating the performance of GFR-estimating equations in older adults with or without diabetes and which equation is most applicable in this group is also unknown.

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