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Original article| Volume 102, P97-103, August 2022

Diagnostic approaches to syncope in Internal Medicine Departments and their effect on mortality

  • Ehud Galron
    Affiliations
    Department of Medicine F. Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel

    Recanati Autonomic Research Center, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel
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  • Orli Kehat
    Affiliations
    I-Medata AI Center, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel
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  • Ahuva Weiss-Meilik
    Affiliations
    I-Medata AI Center, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel
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  • Raffaello Furlan
    Affiliations
    Internal Medicine, Humanitas Research Hospital, Humanitas University, Rozzano, Italy
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  • Giris Jacob
    Correspondence
    Corresponding author at: Department of Medicine F and Recanati Center, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.
    Affiliations
    Department of Medicine F. Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel

    Recanati Autonomic Research Center, Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel
    Search for articles by this author

      Highlights

      • This is the first study to reveal differences in the approach to the diagnosis of patients admitted with syncope to Internal Medicine Departments and their effect on mortality.
      • Despite large variations in the number of diagnostic tests performed between departments, the mortality is not affected.
      • This is a further proof that a cost-effective personalized approach does not affect short term outcomes of patients hospitalized with syncope.

      Abstract

      Most data on mortality and investigational approaches to syncope comes from patients presented to emergency departments (ED). The aim of this study is to report intermediate term mortality in syncope patients admitted to Internal Medicine Departments and whether different diagnostic approaches to syncope affect mortality.
      Methods and results A single-center retrospective-observational study conducted at the Tel Aviv "Sourasky" Medical Center. Data was collected from electronic medical records (EMRs), from January 2010 to December 2020. We identified 24,021 patients, using ICD-9-CM codes. Only 7967 syncope patients were admitted to Internal Medicine Departments and evaluated. Logistic regression models were used to determine the effects of diagnostic testing per patient in each department on 30-day mortality and readmission rates. All-cause 30-day mortality rate was 4.1%. There was a significant difference in the number of diagnostic tests performed per patient between the different departments, without affecting 30-day mortality. The 30-day readmission rate was 11.4%, of which 4.4% were a result of syncope.
      Conclusion Syncope patients admitted to Internal Medicine Departments show a 30-day all-cause mortality rate of ∼4%. Despite the heterogeneity in the approach to the diagnosis of syncope, mortality is not affected. This novel information about syncope patients in large Internal Medicine Departments is further proof that the diagnosis of syncope requires a logic, personalized approach that focuses on medical history and a few tailored, diagnostic tests.

      Graphical abstract

      Keywords

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      References

        • Brignole M.
        • Moya A.
        • De Lange F.J.
        • et al.
        ESC guidelines for the diagnosis and management of syncope.
        Eur Heart J. 2018; 39: 1883-1948https://doi.org/10.1093/eurheartj/ehy037
        • Shen W.-.K.
        • Sheldon R.S.
        • Benditt D.G.
        • Cohen M.I.
        • Forman D.E.
        • Goldberger Z.D.
        • et al.
        ACC/AHA/HRS guideline for the evaluation and management of patients with syncope.
        Heart Rhythm. 2017; 14: e155-e217
        • Sample S.
        Incidence and prognosis of syncope.
        N Engl J Med. 2002; 347: 878-885https://doi.org/10.1056/NEJMoa012407
        • Ganzeboom K.S.
        • Mairuhu G.
        • Reitsma J.B.
        • Linzer M.
        • Wieling W.
        • Van Dijk N.
        Lifetime cumulative incidence of syncope in the general population: a study of 549 Dutch subjects aged 35-60 years.
        J Cardiovasc Electrophysiol. 2006; 17: 1172-1176https://doi.org/10.1111/j.1540-8167.2006.00595.x
        • Kenny R.A.
        • Bhangu J.
        • King-Kallimanis BL.
        Epidemiology of syncope/collapse in younger and older western patient populations.
        Prog Cardiovasc Dis. 2013; 55: 357-363https://doi.org/10.1016/j.pcad.2012.11.006
        • Ruwald M.H.
        • Hansen M.L.
        • Lamberts M.
        • et al.
        The relation between age, sex, comorbidity, and pharmacotherapy and the risk of syncope: a Danish nationwide study.
        Europace. 2012; 14: 1506-1514https://doi.org/10.1093/europace/eus154
      1. Malasana G, Brignole M, Daccarett M, Sherwood R, Hamdan MH. The Prevalence and Cost of the Faint and Fall Problem in the State of Utah. 2011;34(March):278-283. doi:10.1111/j.1540-8159.2010.02930.x.

        • Blanc J.J.
        Syncope: Definition, Epidemiology, and Classification.
        Cardiol Clin. 2015; 33 (PMID: 26115819): 341-345https://doi.org/10.1016/j.ccl.2015.04.001
        • Alshekhlee A.
        • Shen W.K.
        • Mackall J.
        • Chelimsky T.C.
        Incidence and mortality rates of syncope in the United States.
        Am J Med. 2009; 122: 181-188https://doi.org/10.1016/j.amjmed.2008.08.024
        • D'Ascenzo F.
        • Biondi-Zoccai G.
        • Reed M.J.
        • et al.
        Incidence, etiology and predictors of adverse outcomes in 43,315 patients presenting to the emergency department with syncope: an international meta-analysis.
        Int J Cardiol. 2013; 167: 57-62https://doi.org/10.1016/j.ijcard.2011.11.083
        • Solbiati M.
        • Bozzano V.
        • Barbic F.
        • et al.
        Outcomes in syncope research: a systematic review and critical appraisal.
        Intern Emerg Med. 2018; 13: 593-601https://doi.org/10.1007/s11739-018-1788-z
        • Serrano L.A.
        • Hess
        • Bellolio M.F.
        • et al.
        Accuracy and quality of clinical decision rules for syncope in the emergency department: A systematic review and meta-analysis.
        Ann Emerg Med. 2010; 56 (e1): 362-373https://doi.org/10.1016/j.annemergmed.2010.05.013
        • Costantino G.
        • Perego F.
        • Dipaola F.
        • et al.
        Short- and long-term prognosis of syncope, risk factors, and role of hospital admission.
        J Am Coll Cardiol. 2008; 51: 11-13https://doi.org/10.1016/j.jacc.2007.08.059
        • Sun BC.
        Quality-of-life, health service use, and costs associated with syncope.
        Prog Cardiovasc Dis. 2013; 55: 370-375https://doi.org/10.1016/j.pcad.2012.10.009
        • Dipaola F.
        • Costantino G.
        • Perego F.
        • et al.
        San Francisco syncope Rule, osservatorio epidemiologico sulla Sincope nel Lazio risk score and clinical judgment in the assessment of short-term outcome of syncope.
        Am J Emerg Med. 2010; 28: 432-439https://doi.org/10.1016/j.ajem.2008.12.039
        • Savage D.D.
        • Corwin L.
        • McGee D.L.
        • Kannel W.B.
        • Wolf PA.
        Epidemiologic features of isolated syncope: the framingham study.
        Stroke. 1985; 16: 626-629https://doi.org/10.1161/01.STR.16.4.626
        • Solbiati M.
        • Casazza G.
        • Dipaola F.
        • et al.
        Syncope recurrence and mortality: a systematic review.
        Europace. 2014; 17: 300-308https://doi.org/10.1093/europace/euu327
        • Ricci F.
        • Sutton R.
        • Palermi S.
        • et al.
        Prognostic significance of noncardiac syncope in the general population: a systematic review and meta-analysis.
        J Cardiovasc Electrophysiol. 2018; 29: 1641-1647https://doi.org/10.1111/jce.13715
        • Van Dijk N.
        • Boer K.R.
        • Colman N.
        • et al.
        High diagnostic yield and accuracy of history, physical examination, and ECG in patients with transient loss of consciousness in FAST: the fainting assessment study.
        J Cardiovasc Electrophysiol. 2008; 19: 48-55https://doi.org/10.1111/j.1540-8167.2007.00984.x
        • Sheldon R.S.
        • Grubb B.P.
        • Olshansky B.
        • et al.
        Heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope.
        Hear Rhythm. 2015; 12: e41-e63https://doi.org/10.1016/j.hrthm.2015.03.029
        • Recchia D.
        • Barzilai B.
        Echocardiography in the evaluation of patients with syncope.
        J Gen Intern Med. 1995; 10: 649-655https://doi.org/10.1007/BF02602755
        • Sarasin F.P.
        • Junod A.F.
        • Carballo D.
        • Slama S.
        • Unger P.F.
        • Louis-Simonet M.
        Role of echocardiography in the evaluation of syncope: a prospective study.
        Heart. 2002; 88: 363-367https://doi.org/10.1136/heart.88.4.363
        • Kapoor W.N.
        Primary care - syncope.
        N Engl J Med. 2000; 343: 1856-1862https://doi.org/10.1056/NEJM200012213432507
        • Pournazari P.
        • Oqab Z.
        • Sheldon R.
        Diagnostic value of neurological studies in diagnosing syncope: a systematic review.
        Can J Cardiol. 2017; 33: 1604-1610https://doi.org/10.1016/j.cjca.2017.04.004
        • Mendu M.L.
        • McAvay G.
        • Lampert R.
        • Stoehr J.
        • Tinetti ME.
        Yield of diagnostic tests in evaluating syncopal episodes in older patients.
        Arch Intern Med. 2009; 169: 1299-1305https://doi.org/10.1001/archinternmed.2009.204
        • Farwell D.J.
        • Sulke A.N.
        Does the use of a syncope diagnostic protocol improve the investigation and management of syncope?.
        Heart. 2004; 90: 52-58https://doi.org/10.1136/heart.90.1.52
        • Ungar A.
        • Tesi F.
        • Chisciotti V.M.
        • et al.
        Assessment of a structured management pathway for patients referred to the emergency department for syncope: results in a tertiary hospital.
        Europace. 2016; 18: 457-462https://doi.org/10.1093/europace/euv106
        • Smars P.A.
        • Decker W.W.
        • Shen W.K.
        Syncope evaluation in the emergency department.
        Curr Opin Cardiol. 2007; 22: 44-48https://doi.org/10.1097/HCO.0b013e32801173d7
        • McCarthy F.
        • McMahon C.G.
        • Geary U.
        • Plunkett P.K.
        • Kenny R.A.
        • Cunningham CJ.
        Management of syncope in the emergency department: a single hospital observational case series based on the application of European society of cardiology guidelines.
        Europace. 2009; 11: 216-224https://doi.org/10.1093/europace/eun323
        • Shen W.K.
        • Traub S.J.
        • Decker WW.
        Syncope management unit: evolution of the concept and practice implementation.
        Prog Cardiovasc Dis. 2013; 55: 382-389https://doi.org/10.1016/j.pcad.2012.11.001
        • Sousa P.
        • Marques N.
        • Faria R.
        • et al.
        Syncope unit: experience of a center using diagnostic flowcharts for syncope of uncertain etiology after initial assessment.
        Rev Port Cardiol. 2013; 32 (English Ed): 581-591https://doi.org/10.1016/j.repce.2013.09.004
        • Viqar-Syed M.
        • Bradley D.J.
        • Shen WK.
        Syncope units: Impact on patient care and health-related costs.
        Cardiol Clin. 2013; 31: 39-49https://doi.org/10.1016/j.ccl.2012.10.006
        • Dan G.A.
        • Scherr D.
        • Jubele K.
        • et al.
        Contemporary management of patients with syncope in clinical practice: an EHRA physician-based survey.
        Europace. 2020; 22: 980-987https://doi.org/10.1093/europace/euaa085
        • Shen W.K.
        • Decker W.W.
        • Smars P.A.
        • et al.
        Syncope evaluation in the emergency department study (seeds): a multidistiplinary approach to syncope management.
        Circulation. 2004; 110: 3636-3645https://doi.org/10.1161/01.CIR.0000149236.92822.07
        • Brignole M.
        • Benditt D.G.
        Syncope-An Evidence-Based Approach.
        2nd ed. Springer, 2020https://doi.org/10.1007/978-3-030-44507-236
        • Costantino G.
        • Sun B.C.
        • Barbic F.
        • et al.
        Syncope clinical management in the emergency department: a consensus from the first international workshop on syncope risk stratification in the emergency department.
        Eur Heart J. 2016; 37: 1493-1498https://doi.org/10.1093/eurheartj/ehv378
        • Blanc J.J.
        • L'Her C.
        • Touiza A.
        • Garo B.
        • L'Her E.
        • Mansourati J.
        Prospective evaluation and outcome of patients admitted for syncope over a 1 year period.
        Eur Heart J. 2002; 23: 815-820https://doi.org/10.1053/euhj.2001.2975
        • Sun B.C.
        • Emond J.A.
        • Camargo CA.
        Direct medical costs of syncope-related hospitalizations in the United States.
        Am J Cardiol. 2005; 95: 668-671https://doi.org/10.1016/j.amjcard.2004.11.013
        • Brignole M.
        • Ungar A.
        • Bartoletti A.
        • et al.
        Standardized-care pathway vs. usual management of syncope patients presenting as emergencies at general hospitals.
        Europace. 2006; 8: 644-650https://doi.org/10.1093/europace/eul071
        • Kühne M.
        • Schaer B.
        • Moulay N.
        • Sticherling C.
        • Osswald S.
        Holter monitoring for syncope: diagnostic yield in different patient groups and impact on device implantation.
        QJM. 2007; 100: 771-777https://doi.org/10.1093/qjmed/hcm104
        • Bass E.B.
        • Curtiss E.I.
        • Arena V.C.
        • et al.
        The duration of Holter monitoring in patients with syncope. Is 24 h enough?.
        Arch Intern Med. 1990; 150: 1073-1078https://doi.org/10.1001/archinte.150.5.1073
        • Woelfel A.K.
        • Simpson R.J.
        • Gettes L.S.
        • Foster J.R.
        Exercise-induced distal atrioventricular block.
        J Am Coll Cardiol. 1983; 2: 578-581https://doi.org/10.1016/S0735-1097(83)80288-5
        • Grossman S.A.
        • Fischer C.
        • Lipsitz L.A.
        • et al.
        Predicting adverse outcomes in syncope.
        J Emerg Med. 2007; 33: 233-239https://doi.org/10.1016/j.jemermed.2007.04.001
        • Radack K.L.
        Syncope. Cost-effective patient workup.
        Postgrad Med. 1986; 80: 169-178https://doi.org/10.1080/00325481.1986.11699458
        • Sandhu R.K.
        • Sheldon R.S.
        • Savu A.
        • Kaul P.
        Nationwide trends in syncope hospitalizations and outcomes from 2004 to 2014.
        Can J Cardiol. 2017; 33: 456-462https://doi.org/10.1016/j.cjca.2016.11.005
        • Kadri A.N.
        • Abuamsha H.
        • Nusairat L.
        • et al.
        Causes and predictors of 30-day readmission in patients with syncope/collapse: a nationwide cohort study.
        J Am Heart Assoc. 2018; 7: 1-16https://doi.org/10.1161/JAHA.118.009746
        • Ruwald M.H.
        • Hansen M.L.
        • Lamberts M.
        • et al.
        Accuracy of the ICD-10 discharge diagnosis for syncope.
        Europace. 2013; 15: 595-600https://doi.org/10.1093/europace/eus359
        • Furlan L.
        • Solbiati M.
        • Pacetti V.
        • et al.
        Diagnostic accuracy of ICD‑9 code 780.2 for the identification of patients with syncope in the emergency department.
        Clin Auton Res. 2018; : 1-6https://doi.org/10.1007/s10286-018-0509-z
        • Sun B.C.
        • Derose S.F.
        • Liang L.J.
        • et al.
        Predictors of 30-day serious events in older patients with syncope.
        Ann Emerg Med. 2009; 54 (e5): 769-778https://doi.org/10.1016/j.annemergmed.2009.07.027