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Systemic diseases associated with a diagnosis of achalasia: A case-control study with the All of Us research program

      Highlights

      • Achalasia is an idiopathic disorder characterized by degeneration of esophageal myenteric neurons.
      • Enteric neuropathies secondary to systemic diseases have been implicated in the pathogenesis of achalasia.
      • The All of Usresearch program database from the National Institutes of Health (NIH) allows for the examination of achalasia and systemic disease associations.
      • A diagnosis of achalasia is associated with several autoimmune conditions including systemic scleroderma, rheumatoid arthritis, and Guillain-Barré syndrome.
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