Primary nephrotic syndrome (PNS) is characterized by massive proteinuria, hypoproteinemia,
edema and hyperlipidemia. Angiopoietin like protein 4 (ANGPTL4) is a secretory glycoprotein
and belongs to the angiopoietin-like protein family. It's well known that ANGPTL4
is a key regulator of lipid metabolism and has been widely reported in metabolic diseases
and cardiovascular diseases [
[1]
]. Recently, it was reported that ANGPTL4 secreted by glomerular podocytes aggravates
podocyte injury and it is closely related to proteinuria in rats with nephrotic syndrome
(NS) [
[2]
].To read this article in full you will need to make a payment
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References
- Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism.J Lipid Res. 2021; 62: 100150-100160
- Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome.Nat Med. 2011; 17: 117-122
- The nephrotic syndrome.N Engl J Med. 1998; 338: 1202-1211
- Lipid accumulation and chronic kidney disease.Nutrients. 2019; 11: 722-742
- Lipidlowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.Proc Natl Acad Sci U S A. 2007; 104: 11766-11771
Article info
Publication history
Published online: June 24, 2022
Accepted:
June 22,
2022
Received:
June 4,
2022
Identification
Copyright
© 2022 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.
