Advertisement

Persistent FDG uptake in large vessels and risk of relapse in giant cell arteritis

  • Deborah Eshagh
    Affiliations
    Service de Médecine Interne, Hôpital Bichat, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
    Search for articles by this author
  • Arthur Mageau
    Affiliations
    Service de Médecine Interne, Hôpital Bichat, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France

    Université Paris Cité, Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252, Faculté de Médecine site Bichat, Laboratoire d'Excellence Inflamex, Paris, France
    Search for articles by this author
  • Thomas Papo
    Affiliations
    Service de Médecine Interne, Hôpital Bichat, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
    Search for articles by this author
  • Khadija Benali
    Affiliations
    Service de Médecine Nucléaire, Hôpital Bichat, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
    Search for articles by this author
  • Karim Sacre
    Correspondence
    Corresponding author at: Department of Internal Medicine, Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France.
    Affiliations
    Service de Médecine Interne, Hôpital Bichat, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France

    Université Paris Cité, Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252, Faculté de Médecine site Bichat, Laboratoire d'Excellence Inflamex, Paris, France
    Search for articles by this author
Published:September 09, 2022DOI:https://doi.org/10.1016/j.ejim.2022.08.033
      Giant cell arteritis (GCA) is a large vessel vasculitis that typically involves the extracranial branches of the aorta [
      • Weyand C.M.
      • Goronzy J.J.
      Medium- and Large-Vessel Vasculitis.
      ]. Steroids and anti-IL6 are highly effective in obtaining remission but the risk of relapses remains high, especially once treatments are withdrawn [
      • Stone J.H.
      • Tuckwell K.
      • Dimonaco S.
      • et al.
      Trial of tocilizumab in giant-cell arteritis.
      ,
      • Martinez-Lado L.
      • Calvino-Diaz C.
      • Pineiro A.
      • Dierssen T.
      • Vasquez-Rodriguez T.R.
      • Miranda-Filloy J.A.
      • Lopez-Diaz M.J.
      • Blanco R.
      • Llorca J.
      • Gonzalez-Gay M.A.
      Relapses and recurrences in giant cell arteritis : a population-based study of patients with biospy-proven disease from northwestern Spain.
      ]. 18F-fluorodeoxyglucose-positron emission tomography (FDG/PET CT) is now recognized as a powerful tool for GCA diagnosis [
      • Bienvenu B.
      • Ly K.H.
      • Lambert M.
      • Agard C.
      • Andre M.
      • Benhamou Y.
      • Bonnotte B.
      • De boysson H.
      • Espitia O.
      • Fau G.
      • Fauchais A.-.L.
      • Gallateau-Sallé F.
      • Haroche J.
      • Heron E.
      • Lapébie F.X.
      • Liozon E.
      • Luong Nguyen L.B.
      • Magnant L.
      • Manrique A.
      • Matt M.
      • de Menthon M.
      • Mouthon L.
      • Puechal X.
      • Pugnet G.
      • Quemeneur T.
      • Regent A.
      • Saadoun D.
      • Samson M.
      • Sene D.
      • Smets P.
      • Yelnik C.
      • Saillier L.
      • Mahr A.
      Management of giant cell arteritis : recommandations of the frencg study group of large vessel vasculitis.
      ,
      • Prieto-Gonzalez S.
      • Depetris M.
      • Garcia-Martinez A.
      • Espigol-Frigole G.
      • Tavera-Bahillo I.
      • Corbera- Bellata M.
      • et al.
      Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study.
      ,
      • Lariviere D.
      • Benali K.
      • Coustet B.
      • Pasi N.
      • Hyafil F.
      • Klein I.
      • Chauchard M.
      • Alexandre J.F.
      • Goulenok T.
      • Dossier A.
      • Dieude P.
      • Papo T.
      • Sacre K.
      Positron emission tomography and computed tomography angiography for the diagnosis of giant cell arteritis: a real-life prospective study.
      ]. On the other hand, studies testing the ability of FDG/PET CT to predict the risk of relapse in GCA are scarce [
      • Blockmans D.
      • de Ceuninck L.
      • Vanderschueren S.
      • Knockaert D.
      • Mortelmans L.
      • Bobbaers H.
      Repetitive 18F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a prospective study of 35 patients.
      ,
      • Galli E.
      • Muratore F.
      • Mancuso P.
      • Boiardi L.
      • Marvisi C.
      • Besutti G.
      • Spaggiari L.
      • Casali M.
      • Versari A.
      • Giorgi Rossi P.
      • Salvarani C
      The role of PET/CT in disease activity assessment in patients with large vessel vasculitis.
      ]. Our group is contributing reducing the lack of knowledge with a study whose aim is to analyze FDG uptake in large vessels at diagnosis and follow-up along with clinical outcome in patients with GCA.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Weyand C.M.
        • Goronzy J.J.
        Medium- and Large-Vessel Vasculitis.
        N Engl J Med. 2003; 349 (Jul 10): 160-169
        • Stone J.H.
        • Tuckwell K.
        • Dimonaco S.
        • et al.
        Trial of tocilizumab in giant-cell arteritis.
        N Engl J Med. 2017; 377: 317-328
        • Martinez-Lado L.
        • Calvino-Diaz C.
        • Pineiro A.
        • Dierssen T.
        • Vasquez-Rodriguez T.R.
        • Miranda-Filloy J.A.
        • Lopez-Diaz M.J.
        • Blanco R.
        • Llorca J.
        • Gonzalez-Gay M.A.
        Relapses and recurrences in giant cell arteritis : a population-based study of patients with biospy-proven disease from northwestern Spain.
        Medicine (Baltimore). 2011; 90 (May): 186-193
        • Bienvenu B.
        • Ly K.H.
        • Lambert M.
        • Agard C.
        • Andre M.
        • Benhamou Y.
        • Bonnotte B.
        • De boysson H.
        • Espitia O.
        • Fau G.
        • Fauchais A.-.L.
        • Gallateau-Sallé F.
        • Haroche J.
        • Heron E.
        • Lapébie F.X.
        • Liozon E.
        • Luong Nguyen L.B.
        • Magnant L.
        • Manrique A.
        • Matt M.
        • de Menthon M.
        • Mouthon L.
        • Puechal X.
        • Pugnet G.
        • Quemeneur T.
        • Regent A.
        • Saadoun D.
        • Samson M.
        • Sene D.
        • Smets P.
        • Yelnik C.
        • Saillier L.
        • Mahr A.
        Management of giant cell arteritis : recommandations of the frencg study group of large vessel vasculitis.
        Rev Med Interne. 2016; 37 (Mar): 154-165
        • Prieto-Gonzalez S.
        • Depetris M.
        • Garcia-Martinez A.
        • Espigol-Frigole G.
        • Tavera-Bahillo I.
        • Corbera- Bellata M.
        • et al.
        Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study.
        Ann Rheum Dis. 2014; 73: 1388-1392
        • Lariviere D.
        • Benali K.
        • Coustet B.
        • Pasi N.
        • Hyafil F.
        • Klein I.
        • Chauchard M.
        • Alexandre J.F.
        • Goulenok T.
        • Dossier A.
        • Dieude P.
        • Papo T.
        • Sacre K.
        Positron emission tomography and computed tomography angiography for the diagnosis of giant cell arteritis: a real-life prospective study.
        Medicine (Baltimore). 2016; 95 (Jul): e4146
        • Blockmans D.
        • de Ceuninck L.
        • Vanderschueren S.
        • Knockaert D.
        • Mortelmans L.
        • Bobbaers H.
        Repetitive 18F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a prospective study of 35 patients.
        Arthritis Rheum. 2006; 55: 131-137
        • Galli E.
        • Muratore F.
        • Mancuso P.
        • Boiardi L.
        • Marvisi C.
        • Besutti G.
        • Spaggiari L.
        • Casali M.
        • Versari A.
        • Giorgi Rossi P.
        • Salvarani C
        The role of PET/CT in disease activity assessment in patients with large vessel vasculitis.
        Rheumatology. 2022; 00: 1-8
        • Hunder G.G.
        • Bloch D.A.
        • Michel B.A.
        • Stevens M.B.
        • Arend W.P.
        • Calabrese L.H.
        • Edworthy S.M.
        • Fauci A.S.
        • Leavitt R.Y.
        • Lie J.T.
        • et al.
        The American college of rheumatology 1990 criteria for the classification of giant cell arteritis.
        Arthritis Rheum. 1990; 33: 1122-1128
        • Grayson P.C.
        • Alehashemi S.
        • Bagheri A.A.
        • et al.
        18F-fluorodeoxyglucose-positron emission tomography as an imaging biomarker in a prospective, longitudinal cohort of patients with large vessel vasculitis.
        Arthritis Rheumatol. 2018; 70: 439-449