- •Marchiafava-Bignami disease is a rare disorder associated with chronic alcohol consumption.
- •Clinicians should keep a high level of suspicion since clinical presentation is highly variable.
- •Diagnosis relies on MRI findings correlated with a context of alcohol abuse and malnutrition.
- •Brain MRI usually shows cytotoxic lesions of the corpus callosum.
- •Early treatment with intravenous thiamine is associated with a better prognosis.
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- Clinicoradiologic subtypes of Marchiafava-Bignami disease.J Neurol. 2004; 251: 1050-1059https://doi.org/10.1007/s00415-004-0566-1
- Clinical and radiological features of Marchiafava-Bignami disease.Medicine (Baltimore). 2018; 97: e9626https://doi.org/10.1097/MD.0000000000009626
- Diagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases.J Neurol Neurosurg Psychiatry. 2014; 85: 168-173https://doi.org/10.1136/jnnp-2013-305979