Acute necrosis of the corpus callosum

Published:October 12, 2022DOI:


      • Marchiafava-Bignami disease is a rare disorder associated with chronic alcohol consumption.
      • Clinicians should keep a high level of suspicion since clinical presentation is highly variable.
      • Diagnosis relies on MRI findings correlated with a context of alcohol abuse and malnutrition.
      • Brain MRI usually shows cytotoxic lesions of the corpus callosum.
      • Early treatment with intravenous thiamine is associated with a better prognosis.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Heinrich A.
        • Runge U.
        • Khaw A.V.
        Clinicoradiologic subtypes of Marchiafava-Bignami disease.
        J Neurol. 2004; 251: 1050-1059
        • Dong X.
        • Bai C.
        • Nao J.
        Clinical and radiological features of Marchiafava-Bignami disease.
        Medicine (Baltimore). 2018; 97: e9626
        • Hillbom M.
        • Saloheimo P.
        • Fujioka S.
        • Wszolek Z.K.
        • Juvela S.
        • Leone M.A.
        Diagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases.
        J Neurol Neurosurg Psychiatry. 2014; 85: 168-173