Non-infectious gastrointestinal manifestations of Good syndrome

Published:November 19, 2022DOI:
      Good syndrome is a rare adult-onset immunodeficiency syndrome, typically characterized by thymoma and hypogammaglobulinemia. Its clinical manifestations are highly variable, and concurrent non-infectious organ involvements secondary to immune dysregulation have been increasingly recognized, such as myasthenia gravis and immune-mediated cytopenias [
      • Shi Y.
      • Wang C.
      When the good syndrome goes bad: a systematic literature review.
      ]. Among them, gastrointestinal manifestations resembling inflammatory bowel diseases or celiac disease were only described in case reports or small series; however, their clinical features, endoscopic and histologic findings remain largely undefined, and the optimal treatment as well as long-term outcomes are also not established given the rarity. Therefore, we aimed to comprehensively summarize the non-infectious gastrointestinal manifestations in patients with Good syndrome using a systematic literature review approach.


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