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Treatment efficacy of fecal microbiota-based live biotherapeutics (RBX2660) for the prevention of recurring Clostridioides difficile infection

Published:December 28, 2022DOI:https://doi.org/10.1016/j.ejim.2022.12.020

      Highlights

      • C. difficile infections (CDI) are potentially deadly and serious infections.
      • Around 35% of CDI cases recur despite antibiotic treatment.
      • This meta-analysis pooled 580 participants across 6 trials.
      • Odds ratio of 1.82 (95% CI = 1.37–2.41) was reported favoring fecal microbiota use.
      • In-treatment group efficacy was 72% (95% CI = 68–76%).

      Abbreviations:

      CDI (Clostridioides Difficile Infection), CI (Confidence Interval), DF (Degrees of Freedom), FDA (Food and Drug Administration)
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      References

      1. FDA. November 30, 2022 Summary Basis for Regulatory Action - REBYOTA. 2022. Available from: https://www.fda.gov/media/163879/download#:∼:text=The%20requested%20indication%20for%20REBYOTA,combination%20product%20for%20rectal%20administration. Accessed December 10, 2022.

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