Pre-frailty is a condition that precedes frailty; in 2001, Linda Fried and colleagues
defined pre-frailty as the presence of 1 or 2 out of the 5 Fried criteria [
[1]
]. Hence, pre-frail older adults represent an intermediate category between normal
and frail older adults. Comorbidities are known to play a pivotal role in frailty,
in addition to contributing to increasing healthcare costs [
2
,
3
,
4
]. Hypertension is one of the most common conditions in pre-frailty, and its role in
the onset of frailty remains debated [
- Simpson F.R.
- Justice J.N.
- Pilla S.J.
- Kritchevsky S.B.
- Boyko E.J.
- Munshi M.N.
- et al.
An examination of whether diabetes control and treatments are associated with change
in frailty index across 8 years: an ancillary exploratory study from the action for
health in diabetes (Look AHEAD) trial.
Diabetes Care. 2022;
5
,
6
,
7
]. Similarly, admission and stress hyperglycemia are prevailing risk factors of adverse
outcomes, with or without diabetes [
[8]
,
[9]
]. Nevertheless, to the best of our knowledge, the impact of hyperglycemia in the
pre-frailty to frailty transition has never been investigated hitherto.Keywords
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References
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- An examination of whether diabetes control and treatments are associated with change in frailty index across 8 years: an ancillary exploratory study from the action for health in diabetes (Look AHEAD) trial.Diabetes Care. 2022;
- Hypertension management in older and frail older patients.Circ Res. 2019; 124: 1045-1060
- Physical decline and cognitive impairment in frail hypertensive elders during COVID-19.Eur J Intern Med. 2022; 99: 89-92
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- Prevalence of hyperglycemia and incidence of stress hyperglycemia in hospitalized patients: a retrospective cohort.Eur J Intern Med. 2017; 43 (e15-e7)
- Hyperglycemia drives stent restenosis in STEMI patients.Diabetes Care. 2021; 44 (e192-e3)
- Association between glycemic control and morning blood pressure surge with vascular endothelial dysfunction in type 2 diabetic patients.Diabetes Care. 2014; 37: 644-650
Article info
Publication history
Published online: January 10, 2023
Accepted:
January 5,
2023
Received:
January 3,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
