Detecting organisms in blood is a key determinant in sepsis management [
[1]
] and in optimizing antimicrobial use in hospitalized patients [
- Rello J.
- van Engelen T.S.R.
- Alp E.
- Calandra T.
- Cattoir V.
- Kern W.V.
- et al.
Towards precision medicine in sepsis: a position paper from the European Society of
Clinical Microbiology and Infectious Diseases.
Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2018; 24: 1264-1272https://doi.org/10.1016/j.cmi.2018.03.011
[2]
]. Conway et al. [
[3]
] reported that blood cultures were performed in around one out of five adults admitted
to an internal medicine ward from the Emergency Department (ED) and almost one out
of five of these blood cultures were positive. Globally, 4.2% of the patients admitted
to the Internal Medicine ward had positive blood cultures taken at the ED and these
patients had worse outcomes, namely 30-day mortality and hospital length of stay.
Severity-of-illness at admission and comorbidities were major outcomes’ determinants
whereas the specific identified organism had limited impact.- Conway R.
- Byrne D.G.
- O'Riordan D.
- Silke B.
European Journal Intern Med Prognostic value of positive blood cultures and culture
results on outcomes in emergency medical admissions.
Eur J Intern Med Epub. 2022; (Dec 28) (accessed January 9, 2023)https://doi.org/10.1016/j.ejim.2002.12.05
Keywords
Abbreviations:
ED (Emergency Department), AMS (antimicrobial stewardhip), ECMO (extracorporeal membrane oxygenation)To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2018; 24: 1264-1272https://doi.org/10.1016/j.cmi.2018.03.011
- Optimization of antibiotic therapy at the hospital.Eur J Intern Med. 2022; 106 (Epub 2022 Sep 11): 39-44https://doi.org/10.1016/j.ejim.2022.08.035
- European Journal Intern Med Prognostic value of positive blood cultures and culture results on outcomes in emergency medical admissions.Eur J Intern Med Epub. 2022; (Dec 28) (accessed January 9, 2023)https://doi.org/10.1016/j.ejim.2002.12.05
- Multidisciplinary team review of best practices for collection and handling of blood cultures to determine effective interventions for increasing the yield of true-positive bacteremias, reducing contamination, and eliminating false-positive central line-associated bloodstream infections.Am J Infect Control. 2015; 43: 1222-1237https://doi.org/10.1016/j.ajic.2015.06.030
- Risk factors and clinical outcomes associated with blood culture contamination.Infect Control Hosp Epidemiol. 2022; 43: 291-297https://doi.org/10.1017/ice.2021.111
- Economic health care costs of blood culture contamination: a systematic review.Am J Infect Control. 2019; 47: 963-967https://doi.org/10.1016/j.ajic.2018.12.020
- Analysis of quality antimicrobial agent use in the emergency department of a tertiary care hospital.Emerg Rev Soc Espanola Med Emerg. 2018; 30: 297-302
- Diagnostic stewardship for blood cultures in the emergency department: a multicenter validation and prospective evaluation of a machine learning prediction tool.EBioMedicine. 2022; 82104176https://doi.org/10.1016/j.ebiom.2022.104176
- Antimicrobial stewardship in the emergency department: characteristics and evidence for effectiveness of interventions.Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2021; 27: 204-209https://doi.org/10.1016/j.cmi.2020.10.028
- Rapid diagnostic tests for infectious diseases in the emergency department.Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2021; 27: 182-191https://doi.org/10.1016/j.cmi.2020.02.024
- Novel rapid test for detecting carbapenemase.Emerg Infect Dis. 2020; 26: 793-795https://doi.org/10.3201/eid2604.181655
- Rapid ESBL NP test for rapid detection of expanded-spectrum β-lactamase producers in Enterobacterales.Microb Drug Resist Larchmt N. 2021; 27: 1131-1135https://doi.org/10.1089/mdr.2020.0391
- Detection of pathogenic bacteria from septic patients using 16S ribosomal RNA gene-targeted metagenomic sequencing.Clin Infect Dis Off Publ Infect Dis Soc Am. 2021; 73: 1165-1172https://doi.org/10.1093/cid/ciab349
- T2Bacteria and T2Resistance assays in critically Ill patients with sepsis or septic shock: a descriptive experience.Antibiot Basel Switz. 2022; 11: 1823https://doi.org/10.3390/antibiotics11121823
- Does etiological investigation have an impact on the ooutcomes of community-acquired penumonia?- A prospective cohort study.Eur J Intern Med. 2022; (Epub Ahead of Print)https://doi.org/10.1016/j.ejim.2022.11.034
- Improving antimicrobial use through antimicrobial stewardship in a lower-middle income setting: a mixed-methods study in a network of acute-care hospitals in Viet Nam.J Glob Antimicrob Resist. 2021; 27: 212-221https://doi.org/10.1016/j.jgar.2021.09.006
- Antibiotic stewardship in the intensive care unit. An official american thoracic society workshop report in collaboration with the AACN, CHEST, CDC, and SCCM.Ann Am Thorac Soc. 2020; 17: 531-540https://doi.org/10.1513/AnnalsATS.202003-188ST
- The relevance of drug volume of distribution in antibiotic dosing.Curr Pharm Biotechnol. 2011; 12: 1996-2001https://doi.org/10.2174/138920111798808365
- DALI: defining antibiotic levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic.BMC Infect Dis. 2012; 12: 152https://doi.org/10.1186/1471-2334-12-152
- The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients.Clin Pharmacokinet. 2011; 50: 99-110https://doi.org/10.2165/11539220-000000000-00000
Article info
Publication history
Published online: January 19, 2023
Accepted:
January 16,
2023
Received:
January 10,
2023
Publication stage
In Press Corrected ProofFootnotes
✰Disclaimer: Authors declare no conflicts of interest.
Identification
Copyright
© 2023 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.