Abstract
Although tuberculosis due to Mycobacterium tuberculosis is common among patients with the acquired immunodeficiency syndrome (AIDS), infection
caused by Mycobacterium bovis has rarely been described. Tuberculosis due to multidrug-resistant M. bovis is extremely uncommon. Four cases of HIV-related tuberculosis due to M. bovis are described. Two patients presented had pulmonary disease, the third had a disseminated
infection with M. bovis isolated from blood, bronchoalveolar lavage samples, and sputum, and a fourth patient
had a limited lymphnode involvement. Multidrug-resistant M. bovis was found in three of our patients. The course was fatal in all of the cases, as
with previous multidrug-resistant M. bovis strains. Although the M. bovis infection in the fourth patient was not multidrug-resistant, the patient did not
respond to first-line antituberculous drugs. In summary, M. bovis should be considered a pathogen to be suspected in AIDS patients, especially in endemic
regions, where the possibility of transmission of multiresistant strains should be
seriously considered.
Keywords
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© 1999 Published by Elsevier Inc.
