Advertisement
Brief report| Volume 10, ISSUE 1, P49-52, May 1999

Download started.

Ok

Cardiotoxicity as an adverse effect of 5-fluorouracil

      Abstract

      A patient with a history of coronary artery disease developed chest pain several hours after 5-fluorouracil (5-FU) infusion. Electrocardiograms showed signs of ischemia. Infusion with nitroglycerin provided complete relief from his complaints and normalized the ECG. The literature shows that coronary artery disease increases the risk of ischemic episodes after 5-FU treatment.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Dent R.G
        • McColl I
        5-Fluorouracil and angina.
        Lancet. 1975; 1 (Letter): 347-348
        • Labianca R
        • Beretta G
        • Clerici M
        • Fraschini P
        • Luporini G
        Cardiac toxicity of 5-fluorouracil: a study on 1083 patients.
        Tumori. 1982; 68: 505-510
        • Gradishar W.J
        • Vokes E.E
        • Schilsky R.L
        • Weichselbaum R
        • Panje W
        Vascular events in patients receiving high-dose infusional 5-fluorouracil-based chemotherapy: the University of Chicago experience.
        Med. Pediatr. Oncol. 1991; 19: 8-15
        • Rezkalla S
        • Kloner R.A
        • Ensley J
        • Al Sharaf M
        • Revels S
        • Olivenstein A
        • Bhasin S
        • Kerpel-Fronius S
        • Turi Z.G
        Continuous ambulatory ECG monitoring during fluorouracil therapy: a prospective study.
        J. Clin. Oncol. 1989; 7: 509-514
      1. V.T. DeVita, S. Hellman, S.A. Rosenberg, Adverse effects of treatment, in: Cancer: Principles and Practice of Oncology, 4th edn., Vol. 2, Philadelphia, 1993, p. 2376.

        • Roth A
        • Kolari C
        • Popovic S
        Cardiotoxicity of 5-FU.
        Cancer Chemother. Rep. 1975; 59 (Letter): 1051-1052
        • Pottage A
        • Holt S
        • Ludgate S
        • Langlands A.O
        Fluorouracil cardiotoxicity.
        Br. Med. J. 1978; 1: 547
        • Lieutaud T
        • Brain E
        • Golgran-Toledo D
        • Vincent F
        • Cvitkovic
        • Leclerq B
        • Escudier B
        5-Fluorouracil cardiotoxicity: a unique mechanism for ischaemic cardiopathy and cardiac failure?.
        Eur. J. Cancer. 1996; 32 A (Letter): 368-369
        • Mizuno Y
        • Hokamura Y
        • Kimura T
        • Kimura Y
        • Kaikita K
        • Yasue H
        A case of 5-fluorouracil cardiotoxicity stimulating acute myocardial infarction.
        Jpn. Circ. J. 1995; 59: 303-307
        • Mosseri M
        • Fingert H.J
        • Varticovski L
        • Chokshi S
        • Isner J.M
        In vitro evidence that myocardial ischaemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle.
        Cancer Res. 1993; 53: 3028-3033
        • Cwikiel M
        • Eskilsson J
        • Albertsson M
        • Stavenow L
        The influence of 5-fluorouracil and methotrexaat on vascular endothelium. An experimental study using endothelial cells in the culture.
        Ann. Oncol. 1996; 7: 731-737
        • Patel B
        • Kloner R.A
        • Ensley J
        • Al-Sarraf M
        • Kish J
        • Wynne J
        5-Fluorouracil cardiotoxicity: left ventricular dysfunction and effect of coronary vasodilators.
        Am. J. Med. Sci. 1987; 294: 238-243
        • Schöber C
        • Papageorgiou E
        • Harstrick A
        • Bokemeyer C
        • Mügge A
        • Stahl M
        • et al.
        Cardiotoxicity of 5-fluorouracil in combination with folonic acid in patients with gastrointestinal cancer.
        Cancer. 1993; 72: 2242-2247