Abstract
The potent stimulation of ANP release by alveolar hypoxia raises the possibility that
it might be an indicator of pulmonary emboli, a condition which is frequently not
diagnosed. ANP was examined in hospitalized patients with pulmonary emboli evidenced
by perfusion and ventilation scans, and in two control groups of patients with deep
vein thrombosis or anginal syndrome. ANP was measured on days 1, 3, and 5 of hospitalization,
while the patients were given heparin, and determined by double antibody radioimmunoassay.
The level of ANP was 5 times higher in the pulmonary emboli group than in either of
the control groups on day 1, and 3.5–4 times higher than the control groups on day
5. The ANP level remained low in the two control groups throughout the study. We suggest
that ANP may serve as an indicator of the presence of pulmonary emboli, facilitating
diagnosis of the condition.
Keywords
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Article info
Publication history
Accepted:
March 4,
1999
Received in revised form:
March 1,
1999
Received:
January 8,
1999
Identification
Copyright
© 1999 Published by Elsevier Inc.
