Abstract
Background: Tumor tissue differs from healthy tissue in that its cell kinetics have changed
and because of dislocations in the relationship of individual metabolic pathways to
each other. The objective of the analyses presented was the microcalorimetric measurement
of the resulting differences in energy turnover, exemplified by esophageal tumors.
Methods: For this purpose, the thermal output of eight biopsy samples from squamous cell
carcinomas and four biopsies from Barrett carcinomas was compared with that of 11
samples from normal esophageal mucous membranes at a temperature of 37°C. Results: While the thermal output found for the squamous cell carcinoma was significantly
enhanced by a factor of 2–3 in contrast to the healthy esophageal mucous membranes,
the values found for the adenocarcinoma remained unchanged. Conclusions: Taking the literature into consideration, the different behavioral patterns of the
two carcinoma types can best be explained in terms of a higher degree of glycolysis
in the esophageal adenocarcinoma than in the squamous cell carcinomas. Clinical conclusions
may be drawn with respect to an appropriate, stage-oriented therapy for the treatment
of malignant gastrointestinal tumors.
Keywords
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Article info
Publication history
Accepted:
August 19,
1999
Received in revised form:
July 5,
1999
Received:
July 1,
1999
Identification
Copyright
© 1999 Elsevier Science B.V. Published by Elsevier Inc. All rights reserved.
