Abstract
Background: Reports in the literature consistently expose the role of free radical reactions
in human cardiovascular diseases. Studies in vivo are hindered by the short life span
of free radicals and by the toxicity of trapping substances. Electron spin resonance
(ESR) spectroscopy has thus been suggested as an indirect method for studying free
radical reactions in ischemic heart disease. Methods: ESR spectra were obtained from blood samples of 25 healthy subjects (control group)
and 43 patients with ischemic heart disease. Results: ESR spectra in the control and patients groups reflected a slightly asymmetric singlet
state. Spectra in the patient group had a conspicuously weaker amplitude and were
deformed. Conclusions: The amplitude and shape of ESR signals from blood of patients with ischemic heart
disease may be of diagnostic and prognostic value.
Keywords
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Article info
Publication history
Accepted:
August 30,
1999
Received in revised form:
August 24,
1999
Received:
June 3,
1999
Identification
Copyright
© 1999 Published by Elsevier Inc.
