Abstract
Background: Free radicals have been said to contribute to vascular damage in patients with systemic
sclerosis. The aim of the study was to determine the level of lipid peroxidation products
and antioxidative enzyme activity in patients with systemic sclerosis and in healthy
controls. Methods: 10 women with definite systemic sclerosis and 10 age-matched healthy women were
studied. Results: A significant increase in serum lipid peroxidation product levels (i.e. diene conjugates
and thiobarbituric acid-reactive substances) was found in patients with systemic sclerosis.
These changes were accompanied by a decrease in superoxide dismutase, catalase, and
glutathione peroxidase activity in erythrocyte lysate. Furthermore, there was diminished
activity of glutathione reductase and a depressed total serum level of antioxidants
compared to the controls. Blood thiol group concentration in patients with systemic
sclerosis was also found to be decreased. Conclusions: The results obtained indicate increased oxidative stress in patients with systemic
sclerosis.
Keywords
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Article info
Publication history
Accepted:
July 16,
1999
Received in revised form:
February 4,
1999
Received:
January 21,
1999
Identification
Copyright
© 1999 Published by Elsevier Inc.
