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    • Review Article

      Extrahepatic autoimmunity in autoimmune liver disease

      European Journal of Internal Medicine
      Vol. 59p1–7Published online: October 22, 2018
      • Annarosa Floreani
      • Sara De Martin
      • Maria Francesca Secchi
      • Nora Cazzagon
      Cited in Scopus: 19
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        The most important autoimmune liver disease include: autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. In general, about one in three patients with an autoimmune liver disease have a concomitant extrahepatic autoimmune disease, which may include rheumatological, endocrinological, gastrointestinal, pulmonary or dermatological conditions. The pathogenesis of these conditions includes the production of both innate and adaptive immune responses targeting cholangiocytes as well as different extrahepatic tissues.
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