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      • Review article
        Open Access

        The use of β-blockers in patients with heart failure and comorbidities: Doubts, certainties and unsolved issues

        European Journal of Internal Medicine
        Vol. 88p9–14Published online: April 30, 2021
        • Stefania Paolillo
        • Simona Dell'Aversana
        • Immacolata Esposito
        • Alessandra Poccia
        • Pasquale Perrone Filardi
        Cited in Scopus: 5
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          β-blockers represent a mainstay in the pharmacological approach to patients affected by heart failure with reduced ejection fraction (HFrEF). However, underuse of this class of drugs is still reported, especially in the presence of cardiovascular and non-cardiovascular comorbidities, even if they are not contraindications for prescription of a β-blocker. The prognostic benefit of β-blockers is relevant in the presence of comorbidities, and achievement of the maximum tolerated dose is an important goal to increase their favorable prognostic role.
          The use of β-blockers in patients with heart failure and comorbidities: Doubts, certainties and unsolved issues
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