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Incidence, risk factors, and evolution of venous thromboembolic events in patients diagnosed with pancreatic carcinoma and treated with chemotherapy on an outpatient basis
Venous thromboembolic disease is considered one of the leading causes of morbi-mortality [1,2]. in oncological patients. Cancer multiplies the risk of thromboembolic events 6- or 7-fold compared to the general population without cancer [3,4], and this risk is greater in certain tumor sites and in people receiving chemotherapy. The incidence of VTE in individuals with pancreatic cancer is high, although it varies widely in the literature [5–23] due, in part, to the differences in the populations studied.Response to mepolizumab according to disease manifestations in patients with eosinophilic granulomatosis with polyangiitis
Eosinophilic granulomatosis with polyangiitisAdrenomedullin as a potential biomarker involved in patients with hereditary hemorrhagic telangiectasia
Hereditary hemorrhagic telangiectasia (HHT) or Rendu–Osler–Weber syndrome (ORPHA774) is a rare autosomal dominant vascular disease characterized by telangiectases and larger vascular malformations (VMs) of the pulmonary, cerebral, or hepatic vasculature [1]. The hallmark of HHT is telangiectasis, which is an abnormal communication between an arteriole and a dilated and tortuous venule in the capillary bed. HHT can be diagnosed either through molecular genetic test or using the Curaçao clinical criteria (recurrent epistaxis, cutaneous/mucosal telangiectasia, visceral VMs, and a first-degree family member with HHT) [2,3].Autologous fecal microbiota transplantation can retain the metabolic achievements of dietary interventions
We recently reported that autologous fecal microbiota transplantation (aFMT), derived from the time of maximal weight-loss and administrated in the regain-phase, might preserve weight loss and glycemic control in moderately obese subjects, and is associated with specific microbiome signatures. Here, we sought to explore the global effect of aFMT on adipokines, inflammatory markers and blood cholesterol and on the overall gut microbiome preservation.Patient motivation to lose weight: Importance of healthcare professional support, goals and self-efficacy
Obesity is a global health concern [1]. Multiple complications are associated with overweight and obesity including diabetes, heart disease, musculoskeletal disorders and some cancers, and people with obesity (PwO) are at an increased risk of disability and suffer social stigma [2-5]. In the current time, the risk that obesity poses has been highlighted; it increases the risk for serious complications from viral infections, and in particular is associated with high mortality risk of COVID-19 and H1N1 infections [6-9].The 3Ds – Discussion, diagnosis and direction: Elements for effective obesity care by healthcare professionals
Obesity is a chronic disease associated with multiple health complications [1]. Furthermore, the COVID-19 pandemic has made evident the impact obesity can have on health outcomes, whereby people with obesity (PwO) are more likely to require hospitalisation, require mechanical ventilation and suffer serious complications from the infection than those without obesity [2-6]. As a multifactorial disease, successful weight management requires multidisciplinary care [7-9]. In practice, the care received by PwO is frequently suboptimal, owing to differing perceptions about obesity of healthcare professionals (HCPs) and patients, and clinical barriers such as unavailability or cost of certain treatments and services, and time pressures faced by HCPs [10, 11].Seventeen-year trend (2001–2017) in pacemaker and implantable cardioverter-defibrillator utilization based on hospital discharge database data: An analysis by age groups
National Registries are needed to monitor health care interventions, optimize the resources and utilize them appropriately [1], but are challenging to implement and manage due to the possible lack and/or inadequacy of data. Moreover, considerable human commitment and substantial economic resources are required to ensure high-quality data collection [2]. Currently, participation in Registries is still mainly voluntary, while to achieve comprehensive data, it should be mandatory and ruled at a national level [3].A snapshot of cancer-associated thromboembolic disease in 2018–2019: First data from the TESEO prospective registry
Venous thromboembolism (VTE) is a common cause of morbidity and mortality among patients with cancer [1]. Both pathologies interrelate at a deep biological level with numerous interactions between key elements of the hemostatic system and cancer cell programs [2]. Cancer-associated thrombosis (CAT) falls within a panorama of growing complexity in oncology, with the appearance of new anticoagulant therapies, emerging molecular data [3], and new antineoplastic treatments associated with thrombotic risk.
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