A 32-year-old woman, presented to the Emergency Department (ED) with a 15-day fever, and a sore throat recently associated with a growing abdominal pain. At admission in the ED, the patient had normal vital parameters and her history showed no underlying comorbidities. On physical examination, abdominal tenderness was observed with an important (8/10) left upper quadrant pain associated with a palpable splenomegaly. The rest of the clinical examination was normal except for a mild odynophagia. Six days before the ED admission, the patient had consulted her General Practitioner who prescribed a complete blood test.