A 41-year-old previously healthy man presented with a 3-day history of fevers, headache, abdominal pain, and pruritic rash. The rash began on his forehead and extended to the rest of his body. He had been taking amoxicillin, which he was prescribed at an urgent care, and applying calamine lotion with no improvement in symptoms. He did not take any medications or supplements, including steroids or other immunosuppressive therapies. He did not have recent travel, sick contacts, or tick exposure. Review of systems was negative for changes in vision, sore throat, cough, dyspnea, nausea, vomiting, diarrhea, myalgias, weakness, or dysuria.